Two years after the events of 428: Fūsa Sareta Shibuya de, Maria Ōsawa and Minoru Minorikawa are dispatched as reporters to Shanghai in order to cover the upcoming Shanghai NBCR International Anti-Terrorist Conference. Prior to their current assignment, both Maria and Minoru were survivors of the Shibuya bio-terrorism incident, where Maria was kidnapped by terrorists and was infected by the Ua virus but was cured by her scientist father using an experimental anti-Ua virus vaccine. Maria is later saved by her friend, a Middle Eastern girl named Canaan after being targeted for death by masked...